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The Apothecary Diaries: 8 Riveting Anime with Strong Female Leads and Historical Settings

The Apothecary Diaries

Hello friends! In this article, we will discuss anime similar to The Apothecary Diaries, also known as Kusuriya no Hitorigoto. This anime is set in an ancient Chinese-inspired imperial court where the sharp-witted Maomao, a young apothecary, unravels mysteries and political secrets with her incredible knowledge of medicine. The series highlights her fascinating journey through the court, solving complex cases and slowly gaining recognition for her talents. The Apothecary Diaries is a perfect blend of historical intrigue, wit, and mystery that keeps viewers hooked on Maomao's sharp mind and courage.

Discover a great selection of anime like The Apothecary Diaries, featuring enchanting tales of intrigue, adventure, and personal growth.



Snow White with the Red Hair

Snow White with the Red Hair – A charming fantasy romance anime about love and self-discovery.
Snow White with the Red Hair
  • Season: 2
  • Episodes: 24
  • Genre: Fantasy, Romance, Drama

Snow White with the Red Hair, also known as Akagami no Shirayuki-hime, is a charming fantasy romance anime with a strong-willed heroine, Shirayuki.

Shirayuki is a skilled herbalist who flees her country after being pursued by a prince. She crosses paths with Zen, a prince from a neighboring kingdom, who becomes her close friend and protector. Together, they face political challenges and personal growth while Shirayuki follows her dreams of mastering herbalism.

This anime blends romance, adventure, and self-discovery, making it a perfect recommendation for fans of The Apothecary Diaries who enjoy strong, intelligent heroines and beautifully crafted historical settings.



The Story of Saiunkoku

The Story of Saiunkoku – A captivating political and historical drama with a focus on royal intrigue.
The Story of Saiunkoku
  • Season: 2
  • Episodes: 78
  • Genre: Historical, Romance, Drama

The Story of Saiunkoku, also known as Saiunkoku Monogatari, is a captivating historical drama filled with political intrigue and personal growth.

The story revolves around Shuurei Kou, a determined young woman from a noble family. Despite her financial struggles, she dreams of becoming a government official, a role traditionally forbidden to women. Her journey through the imperial court is filled with challenges, alliances, and romance, as she aims to change the nation from within.

This anime's rich world-building and strong female lead make it an ideal recommendation for fans of The Apothecary Diaries who enjoy stories set in political courts with a focus on female empowerment.



Moriarty the Patriot

Moriarty the Patriot – A gripping psychological mystery with a focus on crime and strategy.
Moriarty the Patriot
  • Season: 1
  • Episodes: 24
  • Genre: Mystery, Psychological, Crime, Historical

Moriarty the Patriot, also known as Yuukoku no Moriarty, offers a fresh perspective on the classic Sherlock Holmes tale, centering on Moriarty’s cunning intellect.

The series follows William James Moriarty, a brilliant professor who, alongside his brothers, seeks to dismantle the oppressive class system in 19th-century England. Using his intellect and strategic mind, Moriarty crafts elaborate plans to outwit the elite and deliver justice.

Fans of The Apothecary Diaries will enjoy this anime’s focus on intricate plots, mystery, and the battle of wits, all within a historical setting where one must navigate the complexities of society and power.

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Spice and Wolf

Spice and Wolf – An intelligent and heartwarming journey with economic twists and a unique love story.
Spice and Wolf
  • Season: 2
  • Episodes: 24
  • Genre: Adventure, Romance, Fantasy, Drama

Spice and Wolf, also known as Ōkami to Kōshinryō, is an enchanting anime that blends economic intrigue with fantasy and romance.

The story follows Kraft Lawrence, a traveling merchant, and Holo, a wolf deity in human form. Together, they embark on a journey across medieval towns, engaging in complex trade negotiations and learning about each other’s personal lives. The pair's bond grows stronger as they navigate the world of commerce and adventure.

Fans of The Apothecary Diaries will appreciate the intellectual storytelling, deep character dynamics, and the historical, merchant-filled backdrop that provides a unique twist on traditional adventure tales.

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Ascendance of a Bookworm

Ascendance of a Bookworm – A heartwarming story of perseverance and the pursuit of knowledge.
Ascendance of a Bookworm
  • Season: 3
  • Episodes: 36
  • Genre: Fantasy, Isekai, Slice of Life, Drama

Ascendance of a Bookworm, also known as Honzuki no Gekokujō, tells the heartwarming tale of a book lover’s determination to bring literature to a medieval world.

After being reincarnated into a world where books are scarce, Urano Motosu, now known as Myne, sets out to create books herself. Her relentless passion for reading and innovation drives her to introduce new techniques and inventions, making her indispensable in her society while overcoming social challenges.

Fans of The Apothecary Diaries will enjoy the protagonist’s intelligence, perseverance, and dedication to changing the world through knowledge, all set in a beautifully crafted historical fantasy setting.



Raven of the Inner Palace

Raven of the Inner Palace – A mysterious journey within an ancient royal court filled with supernatural secrets.
Raven of the Inner Palace
  • Season: 1
  • Episodes: 13
  • Genre: Fantasy, Mystery, Supernatural, Historical

Raven of the Inner Palace, also known as Koukyuu no Karasu, delves into the mysterious life of a young consort who possesses mystical powers within an ancient royal court.

The protagonist, known as the Raven Consort, is a mysterious woman who lives in the inner palace and wields great magical power. Her ability to solve supernatural mysteries brings her closer to the emperor, though the royal court hides many secrets.

Fans of The Apothecary Diaries will appreciate the combination of court intrigue, a clever and enigmatic heroine, and the blending of mystery and magic in a historical setting.



The Twelve Kingdoms

The Twelve Kingdoms – An epic fantasy adventure exploring politics, identity, and fate across mystical kingdoms.
The Twelve Kingdoms
  • Season: 1
  • Episodes: 45
  • Genre: Fantasy, Adventure, Drama, Supernatural

The Twelve Kingdoms, also known as Juuni Kokuki, is an epic fantasy series that explores the political and magical landscape of multiple kingdoms and the fate of their rulers.

The anime follows Youko Nakajima, a high school girl who is transported to a mystical world where she is revealed to be the rightful ruler of one of the twelve kingdoms. The series follows her journey to understand her destiny while navigating the complex political and cultural dynamics of this new world.

Fans of The Apothecary Diaries will appreciate the historical fantasy setting, character growth, and political intrigue in a richly built world where protagonists must rise to meet their challenges.



Yona of the Dawn

Yona of the Dawn – A princess's journey of self-discovery, strength, and reclaiming her kingdom.
Yona of the Dawn
  • Season: 1
  • Episodes: 24
  • Genre: Adventure, Romance, Fantasy, Action, Drama

Yona of the Dawn, also known as Akatsuki no Yona, is an empowering tale of a princess who must reclaim her kingdom after a betrayal shakes her world.

The story follows Yona, a sheltered princess, whose life turns upside down after a coup d'état forces her to flee her kingdom. With the help of her loyal friends, she embarks on a journey to become stronger and take back what was stolen from her. Her evolution from a naive royal to a brave leader is at the heart of the narrative.

Fans of The Apothecary Diaries will enjoy the strong female protagonist,



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